1 Case information [Case 1] Male, 42 years old. He presented to the Department of Otolaryngology with sudden onset of right-sided deafness, tinnitus, ear pain and dizziness. Pure tone audiometry showed severe sensorineural deafness in the right ear. The diagnosis of sudden deafness was made and the patient was admitted to the hospital. He was given betanidine hydrochloride and chuanxiongzine injection intravenously, and developed chest tightness, retrosternal pain and shortness of breath after infusion of about 50 ml, and no abnormality was found on blood pressure measurement and electrocardiogram. The gastroscopy showed inflammatory changes in the mucosa of the lower esophagus and the bulb of the duodenum. He had a history of 15 years of sleep snoring and 8 years of chronic irritating cough, which was obvious at night, in the morning and after a full meal. The patient was diagnosed with gastroesophageal reflux disease (GERD), and was advised to control his diet, change his sleep position, and give cisapride and omeprazole orally, and the burning pain behind the sternum disappeared after 7 days, and the ear symptoms were reduced. Case 2] Male, 33 years old. He was referred to the Department of Otolaryngology for sudden onset of right-sided tinnitus, ear stuffiness and hearing loss. Pure tone audiometry showed severe sensorineural deafness in the right ear. The patient was diagnosed with sudden deafness and treated with vasodilatation and nerve nutrition for 10 days with no improvement in symptoms, and developed retrosternal discomfort, pharyngeal discomfort, cough and nausea, and the patient went back to the internal medicine department. The patient had a history of irritating cough, wheezing, and sleep snoring for 6 years, and was treated with bronchitis for a long time, and the symptoms could be temporarily relieved. x-ray chest X-ray suggested bronchitis; gastroscopy suggested inflammatory changes in the mucosa of the lower esophagus. The diagnosis of GERD was confirmed. The patient was advised to control the diet, change the sleeping position, and give oral cisapride, and the symptoms completely disappeared after half a month. 2.1 Pathogenesis The adult eustachian tube is about 35 mm long, communicating between the tympanic chamber and the nasopharynx, and is normally closed. The presence of eustachian tube dysfunction may have led to the erosion of the tympanic chamber by gastroesophageal reflux fluid and caused related complications, but more cases have yet to be observed. 2.2 Basis of diagnosis Both cases showed burning pain behind the sternum in the lower part of the esophagitis, which was confirmed by gastroscopy and treated effectively with anti-reflux and gastric acid secretion inhibiting drugs, so the diagnosis of GERD can be established. It has been reported that bronchial asthma patients with GERD can aggravate the disease. The disease is also associated with nocturnal sleep apnea, but less frequently reported to cause ear symptoms. These two cases were effectively treated with anti-reflux and suppression of gastric acid secretion, and the ear symptoms were improved at the same time, as well as the chronic cough for many years, suggesting that the ear symptoms and cough may be caused by GERD.