In clinical practice, colon cancer with liver metastases indicates advanced disease, and if there is a chance of surgery, surgical treatment can be considered to remove the primary colon and liver metastases. After surgery, chemotherapy treatment and targeted therapy are mostly adopted. The survival time of patients varies according to their physical condition, the degree of compliance with medical advice, the number and size of liver metastases, and the survival time of patients who are in good health and receive chemotherapy treatment regularly as instructed by physicians. For patients with colon cancer with liver metastasis, if the liver metastasis is a single metastasis, after performing whole abdomen enhancement plus plain CT or MRI, perfecting other related examinations and excluding contraindications to surgery, according to the site of single liver metastasis, we can consider removing the primary foci of colon and single metastasis of liver, and receiving regular chemotherapy after surgery, the survival time is generally longer than usual. Depending on the physical condition and degree of metastasis of different individuals, the survival time varies with the degree of primary lesion lesion.