As material life improves day by day, people’s table culture is getting richer and richer, along with the enjoyment of food at the same time, hidden dangers also followed in the future, hypertension, diabetes, increasingly troubled people’s body and mind. Because of high blood pressure, diabetes brought about by the complications spread throughout the body, is very terrible, I will give you a narrative on the complications of kidney disease, if unfortunately put on high blood pressure, diabetes “hat”, I hope that sufferers must be alert to high blood pressure, diabetes and kidney disease “wolf for wolf “The regular urine routine and micro-albumin test is very important. Early treatment to control urine protein, to prevent the continued progression of kidney disease, delaying the development of the disease to the end-stage renal failure, is very critical. The kidney itself is an organ surrounded by capillaries. It is used to filter toxins from the body and prevent protein, blood cells and other substances from leaking out of the blood vessels. High blood pressure makes the blood pressure in the blood vessels increase, which can make the protein leak out, once the protein leak out will cause damage to the filter system of the kidney, causing a vicious circle. The damage caused over time is difficult to reverse, and the kidney will compensate for the increase in size until early failure. This is why it is not terrible to have hematuria, but terrible to have proteinuria. Diabetic nephropathy is one of the microvascular complications of diabetes and is an important cause of death in diabetic patients. With the continuous improvement of diabetes treatment, the number of people who die from acute complications of diabetes has been greatly reduced, and the life of patients has been significantly prolonged, however, the incidence of various chronic complications of diabetes, including diabetic nephropathy, has been significantly increased. Diabetic nephropathy is broadly defined to include both infectious and vascular lesions. Infectious lesions include pyelonephritis and renal papillary necrosis. Vascular lesions are divided into microvascular and macrovascular lesions. Macrovascular lesions include renal arteriosclerosis (involving the trunk and branches) and renal small arteriosclerosis (involving the human and efferent small arteries). Microangiopathy refers to glomerulosclerosis, which is divided into three types: nodular, exudative and diffuse, and the three can exist separately or in combination. We usually say that diabetic nephropathy is glomerulosclerosis. The most important phenomenon of early diabetic nephropathy is that the urinary albumin excretion is slightly higher than normal, called microalbuminuria, with urinary albumin excretion of 20C200μg/min or 30C300mg/24h or urinary Alb/Cr30-300mg/g. Once clinical proteinuria (urinary protein >0.5g/24h) occurs, glomerular Once clinical proteinuria (urine protein >0.5g//24h) occurs, glomerular function declines progressively and irreversibly. The average duration of proteinuria is 17 years, and the average survival is about 10 years after the onset of proteinuria, with end-stage renal failure occurring in about 25% of patients within 6 years, 50% within 10 years, and 75% within 15 years. Hypertensive nephropathy is a disease of benign small artery nephrosclerosis (also known as hypertensive renal arteriosclerosis) and malignant small artery nephrosclerosis with corresponding clinical manifestations, hypertension and renal failure caused by primary hypertension. There is mostly a history of perennial hypertension, damage to the renal tubules mostly precedes the glomeruli, increased nocturia, decreased urinary concentration, mild urinary changes, mild proteinuria, microscopic hematuria and tubular pattern may be present, and other target organ complications of hypertension are often present. Physical examination findings in hypertensive nephropathy: indicate a persistent increase in general blood pressure (above /Kpa/mmHg); some eyelid and/or lower extremity swelling, enlarged heart borders, etc.; most atherosclerotic retinopathy, when there are streaks of flame-like hemorrhage and cotton wool soft exudate in the fundus, supporting malignant small renal arteriosclerosis, and those diagnosed with hypertensive encephalopathy may have corresponding neurological localization signs. Therefore, for patients with hypertension and diabetes mellitus, there must be prevention of hypertension and diabetes mellitus kidney damage, and if clinical symptoms appear, the urinary routine and urinary microalbumin must be tested promptly to prevent leakage and regret.