Thalassemia, i.e., Pearl Protein Production Disorder Anemia, is a kind of hereditary hemolytic anemia, which cannot be self-checked, and it is recommended to go to the hematology department of local hospitals or hematology specialist hospitals for relevant examinations. Generally speaking, routine blood test, hemoglobin electrophoresis test, blood cell osmotic fragility test, genetic test, etc. are needed. 1. Routine blood test is the first choice for screening thalassemia. In thalassemia, the main signs in routine blood test are small red blood cells and low pigment. 2. Hemoglobin electrophoresis is helpful in the typing diagnosis of this disease. 3. Red blood cell osmotic fragility test often shows reduced osmotic fragility of red blood cells. 4. Since thalassemia is a hereditary disease, genetic analysis through genetic testing is the main test to confirm the diagnosis of thalassemia. Therefore, when patients have symptoms such as pallor and jaundice, they should consult a doctor in time and under the guidance of a physician, do not believe in other unfounded self-checking methods, so as to avoid delaying the condition.