Antigen and nucleic acid testing refers to the new crown antigen and nucleic acid testing, the main difference is that the experimental principle, the detection of substances are different, in addition, the accuracy of antigen testing is lower than nucleic acid testing, antigen test positive people still need to further improve the new crown nucleic acid testing. Antigen detection can only detect surface antigen, which can be detected quickly and does not require much technical requirements. However, it can not amplify the antigen, and the current rapid detection method of antigen detection still has some limitations in sensitivity. The principle of nucleic acid detection is to directly amplify the viral genetic material in the sample, through the fluorescence quantitative PCR on the sample, so it is more sensitive. Antigen and nucleic acid testing are both tests to detect whether the body carries the new coronavirus. The antigen test detects the envelope of the virus, while the nucleic acid test detects the RNA material inside the nucleus; the two tests detect different substances. New crown antigen test can be at home antigen self-test kit test is more convenient, new crown nucleic acid test need to go to the designated institutions, but the antigen test accuracy is lower than the nucleic acid test, if the antigen test is positive, the need for further improvement of the new crown nucleic acid test to nucleic acid test results. When people choose the test to detect the new crown virus, if they find that they are positive, they should promptly report to the local community, and at the same time do a good job of epidemic protection.