A total bile acid of 40 μmol/L requires further treatment if liver disease is present. Normal total bile acid ranges from 0 to 9.67 μmol/L (fasting), the patient’s total bile acid 40 μmol / L, suggesting the possibility of hepatobiliary system diseases, it is recommended that according to the patient’s symptoms and signs, further examination, including liver and gallbladder imaging, etc., to clarify the cause of the disease and then treatment. Elevated total bile acids are often seen in acute hepatitis, cirrhosis, chronic hepatitis, alcoholic liver disease, cholestasis and other diseases. Cholestasis occurs, serum bile acid level is obviously elevated, mainly manifested as yellow skin, yellow sclera, yellow urine and other symptoms. Chronic hepatitis with recurrent hepatic abnormalities requires regular treatment and may progress to cirrhosis if not intervened. The presence of elevated bile acids may also be caused by physiological reasons. It is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.