The difference between chickenpox and hand, foot and mouth disease lies in the different causes, different symptoms and different examinations. 1. Different causes: chickenpox is mainly caused by varicella zoster virus infection, while hand, foot and mouth disease is mainly due to enterovirus infection. 2. Different symptoms: Chickenpox usually occurs with fever for 1~2 days, and the initial rash is red spots and papules, which will change into fluid-filled herpes after a few hours. Hand, foot and mouth disease most of the symptoms are mild, may or may not be accompanied by fever, with hands, feet, mouth, buttocks and other parts of the scattered rash or herpes as the main feature, individual children with severe disease progress faster, death can occur. 3. Differences in examination: patients with varicella zoster will have a normal or increased total white blood cell count, and the percentage of lymphocytes may be elevated. The diagnosis of herpes virus infection is confirmed by antigen detection and nucleic acid testing. Hand, foot, and mouth disease has a normal or decreased white blood cell count, C-reactive protein may generally be elevated, and the diagnosis is confirmed by retaining a throat swab or feces for virologic testing, which may detect a positive test or isolate an enterovirus. Chickenpox and HFMD can have similarities, and if you are unable to make a differential diagnosis on your own, you can visit a hospital for diagnosis and management by a medical professional.