When taking cephalosporin antibiotics, you generally cannot drink alcohol because cephalosporin and alcohol together can easily cause a disulfiram-like reaction, which can be harmful and can lead to death in serious cases. Some cephalosporin antibiotics contain the structure of methylthiotetrazolium group, which when combined with alcohol can inhibit acetaldehyde dehydrogenase in the liver, which is an essential enzyme in the metabolism of alcohol, and the lack of this enzyme prevents the normal metabolism of alcohol, thus leading to the accumulation of acetaldehyde and producing symptoms of acetaldehyde intoxication, such as dizziness, headache, nausea, vomiting and other drunkenness-like reactions. In severe cases, drowsiness, cardiac arrhythmia, respiratory distress, decreased blood pressure and shock may occur. Therefore, alcohol should be avoided in the history of taking cephalosporin antibiotics.