The sensation of ants crawling on the body can be first seen in thalamic lesions. If the patient presents suddenly, it may be due to infarction or hemorrhage in the thalamus, and the patient may have numbness and ant crawling sensation in one limb. If the patient presents gradually, it can also be seen as a thalamic occupancy, and the diagnosis can be confirmed by head examination. The sensation of ants crawling in the body can also be seen in patients with some psychiatric disorders, such as anxiety, depression, schizophrenia, etc. For these psychiatric disorders, patients are advised to consult a psychiatrist and take oral anti-psychotic medications under the guidance of a physician, such as Sertraline and Dextran, which are commonly used in clinical practice.