Geriatric pruritus is mostly generalized, paroxysmal severe itching, and long-term repeated scratching can cause hypertrophic tinea versicolor of the skin, and even secondary bacterial infection, inducing pyoderma and lymphadenitis, etc. Since there are many causes of senile pruritus, once the elderly have itchy skin, especially if there is a long-standing severe itch, they should first go to the hospital for examination and laboratory tests to find out the cause of the disease and treat it accordingly. If it is only simple old-age itchy skin, it should be treated mainly with antihistamines and topical antipruritic drugs. In addition, various irritants should be avoided. Local treatment is based on the principle of antipruritic and emollient. When itching, topical antipruritic drops containing camphor mint, cyproheptadine cream, etc. or corticosteroid creams such as dermatoprost, Wuji cream, etc. can be applied. The local itch is also available for severe itching with corticosteroid injections within the skin lesions. If you have pinworms around the anus, you can take intestinal worms, if you have trichomonas, you can use methotrexate, etc. If you have fungal infections, you need to use antifungal preparations. The antihistamines are mainly taken internally, with non-sedating Xithmin and Cetirizine during the day and sedating antihistamines such as paracetamol and cyproheptadine at night, which have the effect of stopping itching and promoting sleep. It can also be combined with anti-H2 receptor blockers such as methocarbamol or ranitidine. For systemic itching can also be intravenous injection of 10% calcium gluconate or 10% sodium thiosulfate; or intravenous injection of procaine; oral multivitamins (such as Schilkhorn), calcium tablets, etc., also have auxiliary effects on the treatment of itching. If necessary, short-term treatment with some corticosteroids or sex hormones can also be used in small amounts. In male patients, testosterone propionate can be injected intramuscularly. Female patients can take oral vinyl estradiol. The above treatments should be carried out under the guidance of a specialist.