Knee bone pain after playing ball may be caused by meniscus injury, arthritis, synovitis, which can be treated by general treatment, medication (aspirin, celecoxib, etc.), surgery and other methods under the guidance of a doctor. 1. Meniscus injury: the disease is mainly caused by the knee half-flexion, adduction or abduction, gravity extrusion and rotational force and other factors, leading to the patient after playing the ball re-knee bone pain, can be treated by surgery, common surgical methods are: total meniscectomy, partial meniscectomy, meniscus repair, allograft meniscus transplantation and so on. 2. Arthritis: the disease is mainly caused by inflammation, infection, trauma or other factors leading to inflammatory lesions of the joints, patients should pay attention to mechanical injuries, improve the joint movement, can also be treated by drugs, commonly used drugs such as aspirin, ibuprofen and so on. Severe cases can also be treated by surgery, monoarthritis, large arthritis can be treated by variable synovectomy, for the middle and advanced patients in the removal of synovial membrane, but also joint cleaning, bone correction, arthroplasty, arthroplasty, arthroplasty, joint fusion and other treatments. 3. Synovitis: If excessive joint movement, joint injury, cartilage degeneration, osteophytes, etc., will lead to synovitis, which can be treated by medication, commonly used drugs are celecoxib, ibuprofen, indomethacin, etc. for treatment. Serious cases can also be treated by surgery, such as arthroscopic synovectomy, osteotomy, joint fusion, arthroplasty and so on. It is recommended that patients go to regular hospitals in time, under the diagnosis of the doctor, according to the patient’s specific condition, to take targeted treatment. The use of the above drugs need to comply with medical advice.