Neonatal jaundice can be divided into physiologic and pathologic jaundice, physiologic jaundice usually does not need medication, while pathologic jaundice may be treated by phototherapy, blood exchange, medication and so on. 1. Physiological jaundice: It is usually considered that full-term babies with serum bilirubin <221µmol/L and preterm babies with serum bilirubin <256µmol/L are physiological jaundice, and babies’ general condition is usually better, and full-term babies’ jaundice can be eliminated in 5~7 days, not more than 2 weeks at the latest, and the jaundice of preterm babies will be eliminated in 7~9 days, and it can be delayed for up to 3~4 weeks, and usually does not need to take drugs for treatment. 2. Pathologic jaundice: usually appears within 24 hours after birth, bilirubin rises more than 85µmol/L (5mg/dl) per day or >0.5mg/dl per hour; jaundice lasts for a long period of time, >2 weeks for term infants and >4 weeks for preterm infants; jaundice recurs after receding; serum-conjugated bilirubin >34µmol/L (2mg/dl). The etiology may be related to infectious diseases such as neonatal hepatitis and neonatal sepsis, or non-infectious diseases such as hemolytic disease of the newborn, biliary atresia, and breast milk jaundice. Phototherapy is the most commonly used effective and safe method, and blood exchange therapy, which exchanges bilirubin, antibodies, and sensitized red blood cells in the blood, is usually used for those who have failed phototherapy. There are also some medications such as phenobarbital and niclosamide that have some adjunctive therapeutic effects. If newborn jaundice is severe, long lasting or accompanied by other uncomfortable symptoms, parents should bring their babies to the hospital for consultation, to clarify the cause of the disease and follow the doctor’s instructions for treatment.