Swollen hands after being bitten by mosquitoes can be treated with oral antihistamines and topical glucocorticoid cream. Swelling occurs after mosquito bites, is due to the body’s immune response to the components of the mosquito saliva, in addition to swelling there will be itching, pain and other symptoms, which can last several days or even weeks. Oral antihistamines can be anti-allergic, improve itching, preferred cetirizine, loratadine and other second-generation antihistamines. If it is difficult to sleep, you can choose a generation of drugs that have a sedative and sleep-aiding effect, such as Benadryl and Chlorpheniramine maleate. Topical glucocorticoid creams can effectively reduce the inflammation of the affected area, and drugs such as hydrocortisone butyrate, mometasone furoate cream, and halometasone cream can be used. It is recommended to go to the dermatologist after consultation, under the guidance of the doctor to use medication.