CREST syndrome is a subtype of systemic scleroderma, the name derives from the typical manifestations of the disease calcium deposits, Raynaud’s phenomenon, esophageal motor dysfunction, sclerosis of the fingertips, and capillary dilatation, which is most often seen in females, and is prevalent in young adults in their 20s and 30s. Patients present with cutaneous calcium deposits, connective tissue disorders such as dermatomyositis and scleroderma, and in particular the CREST syndrome of cutaneous calcium salts deposits, arterial spasm of the extremities, scleroderma of the fingers, and capillary dilatation. Arterial spasmodic and ischemic symptoms are seen in both hands, small arterial spasmodic disease of the extremities due to dysfunction of the sympathetic nerves innervating the peripheral blood vessels, and esophageal dysfunction manifesting as esophageal dyskinesia with diminished contractility and peristalsis.