Whether or not ezetimibe requires lifelong medication depends on the condition, and patients with cardiovascular disease may need lifelong medication. The mechanism of action of ezetimibe is to inhibit the absorption of cholesterol, which is mainly used in the treatment of hypercholesterolemia. For patients who have developed ischemic cardiovascular and cerebrovascular diseases, or those who are at high risk of cardiovascular and cerebrovascular diseases, it is necessary to take ezetimibe orally for a long period of time, and at the same time, use the combined use of statin lipid-lowering drugs, to control the level of low-density lipoprotein to below 1.4 mmol/L. For patients who do not have satisfactory control of blood lipids, it is necessary to take the drugs for the rest of their lives. Oral statin lipid-lowering drugs can be discontinued if LDL levels are stably controlled, and lifelong oral medication is not required. Adverse reactions of ezetimibe include nausea, vomiting, diarrhea, elevated liver enzymes, pancreatitis, etc. Ezetimibe is contraindicated in patients who are allergic to the drug components, have unexplained elevated liver enzymes, or have severe hepatic impairment. Patients with elevated blood lipids should assess the risk under the guidance of a physician to clarify the need for long-term use.