High glutamyl transpeptidase is only one manifestation, but it depends on the cause of the disease. Generally, the cause of high glutamyl transpeptidase may be alcoholic liver, fatty liver or drug-related hepatitis. In this case, the risk is generally not very high in relative terms. In the case of drug-related hepatitis, normalization is usually possible after stopping the drugs. In the case of alcoholic and fatty liver, relief can be achieved by abstaining from alcohol and avoiding high-fat, oily foods, as well as by doing appropriate physical exercise and, if necessary, giving liver-protective and hepatoprotective treatment. For other causes of high glutamyl transpeptidase, it may cause more serious consequences. First of all, acute and chronic hepatitis, mostly caused by viral hepatitis B in China, can lead to different degrees of cirrhosis under long-term development, and is also prone to liver cancer. As for the high glutamyl transpeptidase caused by extrahepatic biliary obstruction, it depends on the specific cause. If it is caused by stones, it can also cause acute cholangitis, especially acute obstructive purulent cholangitis, which can cause shock and even death. For patients with biliary tract tumors and pancreatic head cancer, it may also cause early death. These tumors, which are generally very malignant, are prone to early metastasis and early recurrence after surgery, and the prognosis is still very poor. In addition, for some other causes of glutamyl transpeptidase, it needs to be determined according to the specific situation. For example, long-term staying up late and fatigue can also cause high glutamyl transpeptidase, but in this case, it can be improved gradually by paying attention to rest and normal life, and no special treatment is needed.