Cholecystitis usually does not cause acid reflux. The main clinical manifestation of cholecystitis is pain in the abdomen due to acute or chronic inflammation of the gallbladder. The main clinical manifestation of cholecystitis is pain in the abdomen. The pain is in the right upper abdomen with radiating pain in the back of the right shoulder, accompanied by nausea and vomiting and fever. In cholecystitis or cholelithiasis, there is often a history of eating fatty foods before the onset of the disease, and the abdominal pain can be continuous. If the pain is severe, radiating from the right upper abdomen to the back of the right shoulder or right scapula, the type of pain present is called biliary colic and is often associated with jaundice, fever, palpable liver or positive Murphy’s sign.