In general, people think that the main symptom of Parkinson’s disease is “shaking, stiffness and slowness”. In fact, in addition to “shaking, stiffness and slowness”, Parkinson’s disease also has many non-motor symptoms, such as nose malfunction, constipation, insomnia, dreaminess, depression, anxiety and so on. Often, these non-motor symptoms come on earlier than motor symptoms. Unfortunately, many people ignore these “Parkinson’s non-motor symptoms”. Most of them take the nose failure to see the ear, nose and throat, constipation to see the gastroenterology, insomnia to see the psychosomatic department and so on “headache, foot” approach. Nose failure: data show that about 50% of Parkinson’s disease patients in the early stage will appear sense of smell loss, but often overlooked. Why is there a loss of smell in Parkinson’s disease? I’m sorry, but the reason is not very clear, just as we still don’t understand “the exact cause of Parkinson’s disease”. But the facts are there: 50% of people with Parkinson’s have a loss of smell. Tip: Loss of smell may be part of the degeneration of nerve cells in Parkinson’s disease, and it’s important to be on the lookout for Parkinson’s disease because it may precede the motor symptoms of Parkinson’s disease. Constipation: Constipation often precedes the motor symptoms of Parkinson’s disease and manifests itself as labored bowel movements that come only once every few days. Unlike nose failure, a specific cause can be found for constipation in Parkinson’s disease – the autonomic nerves are affected and there is a lot of drooling, sweating and the appearance of abnormal oil production, which leads to a reduction of water in the body, resulting in constipation. With Parkinson’s disease, the patient’s whole body will move slowly and stiffly, and intestinal peristalsis will be affected, which also leads to constipation. In addition, Parkinson’s patients commonly used anti-alkaline bile drugs and dopamine drugs have caused constipation. Tip: For constipation, Parkinson’s patients can increase water intake, eat more fiber-rich foods, reduce the dose of anticholinergic drugs under the guidance of the doctor, or take laxative drugs. Insomnia: “Insomnia” is a condition that almost everyone encounters, but Parkinson’s patients seem to be particularly favored, with about 70-80% of patients saying they have insomnia. Old Liu, a Parkinson’s patient, told Prof. Wang Xuelian that he has encountered sleep problems such as difficulty in falling asleep, nightmares, kicking the bed covers, waking up especially easily, and waking up early. He wanted Prof. Wang to prescribe him some sleeping pills. Prof. Wang Xuelian did not prescribe sleeping pills, but adjusted Old Liu’s medicine. A week later, Lao Wang called happily and said he could sleep seven and a half hours a day. Tips: If the sleep disorder of Parkinson’s disease is due to the aggravation of the disease at night, you can add levodopa controlled-release agent before going to bed at night; if there is restless legs syndrome affecting sleep at night, you can add dopamine agonists before going to bed; if you can’t improve your sleep after adjusting the anti-Parkinson’s disease medication, you can choose a sedative sleeping pill. Mental symptoms: Ms. Zhang’s mother-in-law is 75 years old and has suffered from Parkinson’s disease for 12 years and has been treated with medication. She took her mother-in-law to Prof. Wang Xuelian’s clinic and said that her mother-in-law was in a bad mood recently, often in tears alone, and did not say a word for a whole day. She was afraid that something would happen to her mother-in-law, so she took a long vacation and went home to take care of her, but her mother-in-law’s mood was still not good. After understanding, Prof. Wang learned that Ms. Zhang’s mother-in-law had these main symptoms: she could not sleep, her brain was slow to react, there was nothing that could make her feel happy, she worried too much, and her depression was serious. If you find that the elderly in your family are often fidgety, inattentive, depressed, moody, very fatigued and anxious, you should be alert to Parkinson’s disease. This is because these are common non-motor symptoms in Parkinson’s patients and can also precede the onset of motor symptoms. Tips: insomnia, depression, anxiety symptoms of the elderly once a slight “shake stiff and slow” symptoms, to be associated with Parkinson’s disease; if the patient has mental symptoms, need to reduce or even stop using anticholinergics, amantadine, sildenafil, dopamine agonists, compound levodopa, etc.; if the symptoms of the more serious can not reduce the drug, drug, can add Clozapine, Clozapine, Clozapine, Clozapine, Clozapine, Clozapine, Clozapine, and Clozapine. Clozapine, quetiapine and other antipsychotic drugs can be added. Parkinson’s patients should not underestimate the power of “non-motor symptoms”. Parkinson’s disease is a chronic disease that requires long-term treatment, and these “non-motor symptoms” will step by step erode the patient’s enjoyment of life, so that the patient suffers a lot, and even become the culprits of Parkinson’s patients’ hope.