Pioglitazone metformin tablets can not directly play a role in reducing proteinuria, but can reduce blood glucose to alleviate proteinuria caused by diabetic nephropathy, it is recommended to follow the doctor’s instructions to take the drug. Pioglitazone metformin tablets can be used for the treatment of dietary control, exercise based on the use of metformin hydrochloride and pioglitazone hydrochloride combination of type 2 diabetes mellitus patients, as well as type 2 diabetes mellitus patients whose blood glucose is still poorly controlled after using metformin hydrochloride alone. Therefore, for type 2 diabetic patients with proteinuria caused by diabetic nephropathy, metformin pioglitazone tablets are able to alleviate the symptoms of proteinuria by lowering blood glucose in diabetic patients. It should also be noted that this drug should not be used for people who are allergic to pioglitazone, metformin, metabolic acidosis, severe kidney injury and so on. Adverse reactions such as nausea, diarrhea, vomiting, and edema may occur after treatment with this drug. Patients who need to use pioglitazone metformin tablets should be treated under the guidance of a doctor, and should not blindly use the drug on their own.