High gamma-glutamyl transpeptidase indicates the presence of liver damage, which may be caused by fatty liver, liver disease or bile duct disease. It can be treated with a light diet, abstinence from alcohol, the use of drugs and surgery. 1. Fatty liver: high gamma-glutamyl transpeptidase may be a manifestation of fatty liver. You should pay attention to light diet, strengthen exercise, quit smoking and drinking to slow down the development of fatty liver. 2. Liver disease: Liver disease such as acute or chronic hepatitis can cause liver function impairment and gamma-glutamyl transpeptidase elevation, which can be treated with medication. 3. Biliary tract diseases: cholecystitis, gallbladder stones can also cause γ-glutamyl transpeptidase elevation, should pay attention to eat less greasy food, will stimulate the gallbladder contraction, resulting in cholecystitis or gallbladder stones acute attack, choledochal stones can also be done by means of transendoscopic retrograde cholangiopancreatography (ERCP) and other means of stone extraction treatment. When there is a high gamma-glutamyl transpeptidase, you need to go to the hospital in time, under the guidance of the doctor to clarify the cause of the disease and targeted treatment, do not take your own medication, so as not to delay the condition.