More than a decade ago, doctors warned lupus patients against pregnancy and childbirth. On the one hand, the treatment for lupus was not effective in the past, and few patients could achieve remission; on the other hand, pregnancy and childbirth without remission could easily lead to deterioration of the disease, which could be life-threatening in serious cases. With the development of medical technology, most patients with lupus erythematosus can achieve remission. After the disease is in remission, most patients can become pregnant and have children as they wish. The prerequisite for pregnancy in lupus erythematosus is remission of the disease. Hormones can only reduce the symptoms of lupus erythematosus; induction of disease remission depends on immunosuppression. Once the disease is in remission, patients can discuss the timing of pregnancy and childbirth with their doctor. More than half of patients in complete remission can have a pregnancy and childbirth as normal; 30% of patients will experience mild fluctuations during pregnancy and need to adjust their medication on an outpatient basis; about 10% of patients need to be hospitalized for lupus erythematosus treatment; only a few patients will experience significant worsening of their disease and need to terminate their pregnancy. How to grasp the timing of pregnancy? There is no uniform standard for the timing of pregnancy and childbirth. In general, if the hormone is reduced to a small dose (prednisone ≤10mg per day) and this small dose is maintained for more than 6 months, and the blood indicators related to lupus erythematosus are stable on review and the urine test is normal, pregnancy and childbirth can be considered. If the disease is mildly fluctuating after 6 months of low-dose hormone maintenance, it is necessary to discuss the risks of pregnancy and childbirth with an experienced doctor and decide whether to have a pregnancy. In mildly active cases, most pregnancies are successful, although the risk increases during the October pregnancy; in moderately active cases, pregnancy should be temporarily abandoned and the disease should be controlled first. In the current situation, although most patients can achieve complete remission, more than half of them will experience a relapse after a period of remission. Therefore, those who plan to get pregnant should discuss the timing of pregnancy with their doctor when they are in full remission and plan to adjust their medications for pregnancy and childbirth. Some patients do not want to get pregnant when the timing of pregnancy is available, and when they want to get pregnant, their disease is unstable, leading to lifelong regrets. During pregnancy and childbirth, medication should be used with care. Sex hormone changes occur during pregnancy, especially the increase of estrogen and prolactin levels which will lead to the continuous enhancement of the body’s immune response. Therefore, although most lupus erythematosus can be successfully conceived and delivered, there is still a risk of lupus erythematosus activity and exacerbation of symptoms. Moreover, the increased burden on the mother’s heart and kidneys during pregnancy puts the body in a state of stress, which is also a factor in the recurrence of lupus erythematosus. Therefore, in addition to routine obstetric checkups, pregnant women with lupus erythematosus need to visit the rheumatology department regularly to monitor the condition of lupus and seek medical consultation whenever there are symptoms. During pregnancy, care must be taken to ensure the safety of the fetus. Oral prednisone up to 30mg daily has little effect on the fetus; oral azathioprine in late pregnancy also has little effect on the fetus; while dexamethasone, cyclophosphamide and methotrexate can affect fetal development and are contraindicated drugs in pregnancy. Childbirth causes a significant increase in maternal lactogen levels, while high estrogen levels take several months after delivery to slowly decline to non-pregnant levels. Therefore, the postpartum months are a dangerous period for the recurrence of lupus erythematosus. In the past, it was advocated to start high doses of hormones and immunosuppressants immediately after delivery, which is a serious setback for the postpartum weakened mother. In the last two years, we have found that giving oral bromocriptine for two weeks after delivery can rapidly reduce maternal lactogen and estrogen to non-pregnancy levels, which not only reduces the probability of postpartum lupus erythematosus recurrence, but also mitigates the damage to the maternal body, which is both safe and effective. What are the prerequisites for pregnancy in patients with lupus erythematosus? The prerequisite for pregnancy in lupus erythematosus patients is remission of the disease. Hormones can only reduce the symptoms of lupus erythematosus; it is up to immunosuppression to induce remission of the disease. Once the disease is in remission, patients can discuss the timing of pregnancy and childbirth with their doctor. More than half of patients in complete remission can have a pregnancy as normal; 30% of patients will experience mild fluctuations during pregnancy and need to adjust their medication on an outpatient basis; about 10% of patients need to be hospitalized for lupus; and only a few patients will experience significant worsening of their disease and need to terminate their pregnancy. What are the conditions that prevent pregnancy? Pregnancy is contraindicated in patients with active disease or progressive heart, lung, brain or kidney damage. Those with active disease before pregnancy are likely to get worse after pregnancy. The longer the number of years of remission, the lower the rate of deterioration. Some studies have analyzed that those who have been in remission for more than 3 years have a significantly lower rate of deterioration after pregnancy than those whose disease has been stable for less than 3 years.