SLE is a chronic autoimmune disease with multi-system and multi-organ damage. Its clinical symptoms are diverse and early symptoms are often atypical. Most SLE has an insidious onset and complex and variable symptoms, with fever, rash, arthritis or arthralgia being the most common first symptoms. Initially, about 90% of patients have fever, which is usually low or moderate, and high fever can be seen in the acute stage. Some patients have skin and mucous membrane lesions, typically facial butterfly erythema, symmetrical rash or discoid erythema on exposed areas, and some patients have photosensitivity, i.e. rash or rash aggravated by sunlight. In addition, arthritis or arthralgia is also a common symptom, which can present symmetrical multi-joint pain and swelling, with finger, wrist and knee joints being the most common. It should be noted that besides the above-mentioned fever, rash, arthritis or arthralgia as the first symptoms, some patients with SLE may also have systemic manifestations such as fatigue, malaise, loss of appetite, emaciation, or impairment of urinary and blood system functions such as occult nephritis, hypocytosis, mild anemia, thrombocytopenia as the first clinical manifestations. Therefore, women of childbearing age and those with a family history of lupus should consider the possibility of SLE if they develop symptoms and signs involving multiple systemic organs that are difficult to explain by conventional diseases, and seek timely diagnosis and treatment.