Cranial defects are a relatively common disorder in neurosurgery. We live in a complex social environment with various dangers and accidents, and our skull may be damaged in these dangers and accidents. For example, accidental traffic accidents, production safety accidents, falling objects, fights and brawls, as well as craniotomy due to our own cranial diseases, etc. All these cases may eventually lead to cranial defects. Can I fly with cranial defects? During air travel, especially during takeoff and landing, the pressure inside the cabin changes, and many people’s ears and eardrums will have obvious symptoms, such as tinnitus, dorsal air in the ears, and inversion or bulging of the ear drum. For patients with skull defect, before skull repair, the skull defect is only covered by skin, and under the skin is the brain tissue. This situation is easily affected by the external atmospheric pressure, and if the pressure changes a lot, the patient may experience dizziness, headache, and severe patients may have epilepsy. Therefore, patients with skull defects that have not yet been repaired should avoid air travel as much as possible, and can ride safely after the skull repair is completed.