After six months of taking bedaquiline the regression effect is good can be appropriate to reduce the dose or stop, if the regression effect is poor need to continue to take or change the drug. First of all, the mechanism of action of bedaquiline is to affect the ATP synthesis of Mycobacterium tuberculosis by inhibiting the activity of the proton pump of ATP synthase of Mycobacterium tuberculosis, so as to exert antibacterial and bactericidal effects. For this reason, it is mainly used for the treatment of multidrug-resistant tuberculosis in adults. In the drug-resistant tuberculosis treatment program, after taking bedaquiline for 6 months, some of the tuberculosis patients have a better regression effect, and the sputum negative rate at the end of 6 months is also relatively high. However, due to the existence of individual differences, the sputum-negative effect cannot be completely guaranteed. For this group of people, the difficulty of treatment will be relatively increased, and the treatment time will also be relatively prolonged is required to continue to take the drug. If during the process of taking the drug there are intolerable nausea, arthralgia, headache and other adverse reactions, as well as allergic reactions, a certain degree of liver, kidney and other functional insufficiency, then you need to be careful to continue to take the drug. In addition to allergic to the drug, suffering from severe cardiac, hepatic and renal insufficiency patients need to be prohibited; also not recommended for pregnant women, lactating women, children and other groups of people.