There are two common reasons for not being able to sleep after cerebral infarction as follows: 1. Sleep inversion has occurred: Patients with cerebral infarction often have sleep inversion, one is related to the central nervous system injury in the brain, and the other is that patients are bedridden for a long time after cerebral infarction and often sleep during the day leading to too much sleep and cannot fall asleep at night. In this case, you can take oral melatonin receptor modulators, such as agomelatine, which can regulate and restore the normal circadian rhythm. 2. Post-stroke depression may have occurred: Post-stroke depression is a common complication after cerebral infarction. Patients often have depressed mood, cannot be happy, pessimistic, think things in a bad direction, and feel that there is no hope for the future. This affects the patient’s recovery and can also lead to sleep disturbances, with difficulty falling asleep and early awakening as the main manifestations, which can be treated with antidepressants such as duloxetine and escitalopram oxalate tablets.