There is no such thing as how to treat blackheads most effectively. Blackheads are mild acne, and their treatment is based on topical medications, supplemented by systemic medications and general treatment. 1. Topical medication: The first line of medication is vitamin A acid drugs, such as topical adapalene and tazarotene, etc. The second line of topical medication, such as benzoyl peroxide and azelaic acid, can be chosen according to the specific conditions of the patient under the guidance of the physician. 2. Systemic medication: When blackheads develop into moderate or severe acne, oral antibiotics can be taken under the guidance of a physician, commonly used drugs are minocycline, doxycycline, etc., or a combination of oral retinoids such as isotretinoin soft capsules. 3. General treatment: daily should use warm water to wash the face, keep the face clean, do not use ointment cosmetics, moderate labor, avoid staying up late, diet should be light, eat more fresh vegetables, fruits and vitamin-rich foods, avoid spicy, stimulating, greasy food intake. Patients with blackheads, should be standardized under the guidance of a physician, reasonable treatment, if the use of topical ointment, should also observe the reaction of the skin lesions after the use of medication, such as whether there is no local redness, flaking, tightness and other discomforts, if the irritation symptoms are obvious, should also be discontinued to consult with a physician.