Diffuse liver injury refers to widespread damage to liver tissue, with lesions distributed more evenly throughout the liver. Common causes of diffuse liver injury include: hepatitis, alcoholic liver, and fatty liver. 1. Hepatitis: Hepatitis B, Hepatitis A and Hepatitis C are common. Viruses can damage liver cells, leading to hepatocellular necrosis, and also stimulate hepatic stellate cells to generate collagen fibers deposited in the interstitial space of hepatocytes, manifesting as widespread and homogeneous liver injury. 2. Alcoholic liver: alcohol is mainly metabolized in the liver, long-term heavy drinking will aggravate the burden on the liver, thus damaging the liver, and in serious cases, it will cause hepatocyte death, liver fibrosis, cirrhosis, and this kind of injury is generally a diffuse injury. 3. Fatty liver: Long-term consumption of high-fat, high-calorie and high-sugar foods, as well as not paying attention to increasing the amount of exercise, will lead to excessive accumulation of fat in the fat cells, affecting the normal function of the liver cells, which may cause diffuse liver injury in serious cases.