Aortic and coronary atherosclerosis suggests that the patient’s aorta and coronary arteries are sclerotic, and that the cause of the condition needs to be clarified, and prompt treatment may improve the prognosis. Aortic and coronary arteriosclerosis is a commonly used term for examination, meaning that the patient’s aortic and coronary blood vessels are showing signs of sclerosis, and further examination is needed to clarify the cause of the sclerosis and timely treatment. If aortic and coronary artery vascular sclerosis occurs in elderly patients, it is mostly caused by the decrease of elasticity and calcification of the vessel wall, which is a normal physiological degeneration of the elderly, and patients without other underlying diseases and clinical symptoms can be regularly reviewed without special treatment. If aortic and coronary artery vascular sclerosis is caused by the emergence of atherosclerotic plaque, should actively follow the doctor’s instructions to give medication, commonly used antiplatelet aggregation of aspirin, control of blood lipids to stabilize plaque atorvastatin, etc., in order to prevent the plaque from further development or detachment, which will lead to coronary artery disease, infarction and so on, in order to avoid endangering the lives of the patients. Therefore, checking the aorta and coronary artery vascular condition is conducive to clarifying the patient’s vascular lesions, and active treatment under the guidance of professional physicians can improve the patient’s prognosis. The medication needs to strictly follow the doctor’s instructions, and regular review.