Calcification of nodules in the lungs is considered as old lesions, which are due to tuberculosis and require no special treatment, only regular review. Nodules are divided into benign nodules and malignant nodules. If the patient has small nodules with smooth margins and no burr sign, and the clinical symptoms are not obvious, regular review is needed, and CT is reviewed after six months or a year to observe any dynamic changes without drug intervention. If the patient has more nodules with unsmooth margins and burrs, malignant nodules are clinically considered and further bronchoscopy or lung nodule aspiration biopsy needs to be improved to assess whether the nodules are malignant. If the patient is a malignant nodule, surgical treatment, radiotherapy, chemotherapy or targeted cellular drug therapy needs to be considered.