The causes of redness and itching on both sides of the cheeks include atopic dermatitis, rosacea, seborrheic dermatitis, etc., which can be improved with the help of topical and oral medications. 1. Allergic dermatitis: Redness and itching on both sides of the cheeks that occurs after the use of certain cosmetics and other sensitizers, or after the consumption of certain foods or medicines, or after excessive ultraviolet radiation, may be caused by allergic dermatitis. These patients can apply topical tacrolimus ointment, mucopolysaccharide polysulfate cream and other medications to help improve the symptoms of skin allergies, and severe cases need to take oral anti-allergy treatment with medications such as levocetirizine hydrochloride tablets and diclofenac loratadine tablets. 2. Rosacea: Rosacea is a chronic inflammatory dermatosis that occurs in the middle of the face, mainly manifested as persistent erythema and capillary dilatation of the face, which can be accompanied by dryness, burning, itching and other symptoms. This kind of patients can be applied locally fusidic acid cream, erythromycin ointment, tacrolimus ointment and other drugs to help improve the local symptoms, the serious need to take oral doxycycline, minocycline and other drugs to help treatment. 3. Seborrheic dermatitis: redness and itching on both sides of the cheeks, accompanied by greasy flaking symptoms may be caused by seborrheic dermatitis, which mainly occurs in the face of seborrheic overflow areas, and in severe cases, can be extended to the edge of the hairline and the back of the ear. Such patients can apply local sulfur, salicylic acid, tacrolimus ointment and other drugs to help antibacterial and anti-inflammatory, itching obvious people can take oral loratadine, ibastine and other itching sedative, but also appropriate supplementation of vitamin B or zinc to help treatment. It should be noted that the above treatment should be carried out under the guidance of a physician to avoid adverse reactions.