High bilirubin may be caused by liver diseases, such as hepatitis, or by diseases such as cholecystitis and gallstones. 1. Viral hepatitis: Bilirubin may be elevated if you have viral hepatitis. The liver has the function of uptake and transportation, binding and excretion in bilirubin metabolism, and when viral infection occurs in the liver, liver damage causes bilirubin level to rise. 2. Cholecystitis: when suffering from cholecystitis, it can affect the contraction and excretion of the gallbladder, and even the occurrence of cholestasis, which makes bilirubin rise. 3. Gallstones: If gallstones block the common hepatic duct or bile duct, it can lead to bile duct obstruction and obstructive jaundice, and finally make bilirubin increase. There are many other causes of elevated bilirubin, and it is recommended that patients go to regular hospitals in a timely manner to clarify the cause of the disease, and then under the guidance of the doctor to carry out targeted treatment.