Severe heat stroke is also divided into heat cramps, heat exhaustion and pyrexia. In the heat cramps stage, the patient should be moved quickly to a cool and ventilated place, rested properly, given cooling measures, and given saline or solutions containing electrolytes by oral or intravenous infusion, and should be actively prepared for transport to a doctor. The treatment of heat exhaustion and pyrexia should be carried out in a medical institution. First of all, physical and pharmacological methods can be used to rapidly reduce the patient’s temperature, and appropriate fluid supplementation can be used to maintain the patient’s effective circulating blood volume and correct ionic disturbances and acid-base imbalances. During this period, monitoring related to organ function should be strengthened and organ function should be evaluated. Ventilator, blood purification therapy or sub-cold temperature therapy can be used to enhance the maintenance and protection of organ function. The key points of treatment are: first, rapid reduction of the patient’s core temperature; second, early implementation of blood purification therapy with a view to eliminating inflammatory factors and supporting organ function; and third, prevention of DIC. according to the requirements of the 2015 Expert Consensus on Standardized Diagnosis and Treatment of pyrexia, the specific rescue measures can be summarized as early cooling, early volume expansion, early blood purification, early sedation, early tracheal intubation, early correction of coagulation The specific treatment measures can be summarized as early hypothermia, early volume expansion, early hemodialysis, early sedation, early tracheal intubation, early correction of coagulation disorders, early anti-infection, early enteral nutrition, early immune conditioning, and prohibition of surgery during the period of coagulation disorders.