The second day after drinking alcohol, stomach upset can be relieved by dietary adjustments, taking acid-suppressing drugs and drugs to protect the gastric mucosa. As alcohol has a certain irritating effect on the gastrointestinal tract, and alcohol is not fully metabolized after the second day of drinking, it may continue to stimulate the gastrointestinal mucosa, resulting in gastrointestinal mucosal damage caused by symptoms such as gastric pain, gastric distension, nausea, vomiting and other symptoms of dyspepsia. If the symptoms are mild, you can drink some honey water. The fructose in honey can assist in promoting the metabolism of alcohol in the body and alleviate the stimulation of the mucous membrane of the gastrointestinal tract by alcohol, and the water can also dilute the concentration of alcohol. Diet as much as possible to light food, avoid eating spicy stimulation, cold, greasy food, reduce the burden on the gastrointestinal tract, relieve gastrointestinal discomfort. If the patient’s symptoms of gastric distress are more serious, you can take drugs to inhibit the secretion of gastric acid and drugs to protect the mucosa of the gastrointestinal tract under the guidance of a doctor, such as omeprazole and other acid inhibitors can reduce the stimulation of gastric acid on the gastric mucosa, and doxepinolone and other gastrointestinal dynamics drugs can protect the gastric mucosa. Drinking the second day of stomach upset patients should be under the guidance of the doctor to take the appropriate drugs for treatment.