How did oxygen go from being a savior to a killer?

Every year, the winter and spring season of high incidence of whoosh disease. In this season, many old chronic bronchitis, pulmonary heart disease, asthma patients are regular visitors to the hospital. In order to solve their breathing difficulties, doctors mostly let them inhale oxygen. Even some old patients have their own oxygen cylinders at home. Oxygen is a lifesaver for these patients as it relieves the symptoms of difficulty in breathing very quickly. Oxygen seems to be very simple, open the oxygen cylinder and connect the oxygen tube. However, improper use of oxygen can lead to oxygen toxicity, sudden stoppage of breathing and even death. The following is a real example: an elderly patient with pulmonary heart disease, facial skin and lips mucous membranes were cyanotic, weak whistle, the condition is very critical. He was sent to the emergency room, the doctor according to his condition to give him oxygen. The patient’s family saw that the oxygen flow is not on, but also thought that the physician “petty”. Some of his family members said angrily, “Now the hospital is concerned about economic efficiency, not to turn on the oxygen switch, this is going to kill people |”. The patient’s son took advantage of the absence of medical staff, quietly turn on the oxygen flow greatly. Oxygen filter bottle out of a larger bubble flower, which bubble flower in the patient and his family, seems to be the flower of life; however, not long after the patient whistling instead of stopping, the nurses did not notice at first, see the situation immediately to the patient for artificial whistling, busy. At this time, the doctor arrived and found out the problem. After reducing the amount of oxygen, the patient gradually resumed breathing and his color improved. Why did the large amount of oxygen given to the patient cause a cessation of breathing? This is the duality of the effect of oxygen on the human body. As we all know, oxygen is necessary for life activities. Lack of oxygen or insufficient oxygen supply will cause impaired life activities and even death. For example, hemorrhage patients, due to the reduction of blood volume, blood pressure drops, blood supply to all organs of the body is reduced, through the blood supply of oxygen is also seriously insufficient, resulting in many organs due to the lack of oxygen and dysfunction, which is the so-called shock. Another example is coronary artery sclerosis in patients with coronary artery disease, the lumen becomes smaller, blood flow is reduced, resulting in part of the myocardial tissue ischemia and hypoxia, which can cause myocardial infarction, heart failure or arrhythmia in severe cases. The best way to treat hypoxia is to remove the cause of hypoxia. When the cause of hypoxia cannot be removed quickly or is difficult to remove, inhaling high concentrations of oxygen to the patient can quickly improve tissue hypoxia and save the patient’s life. At this time, oxygen can be called the patient’s “savior”. However, when oxygen therapy is not used properly, oxygen can become a “killer”. An example of this is the patient who stopped breathing due to high concentration of oxygen. The patient’s face and lips were blue-purple, and his breathing was weak, indicating that he had type II respiratory failure, which was not only a serious lack of oxygen, but also an accumulation of carbon dioxide in his body. It is right to give oxygen to a patient with respiratory failure. However, it is not better to give more oxygen. Because the whoosh center is regulated by the blood oxygen concentration and carbon dioxide concentration. In the weakening of the whoosh, the lack of oxygen will aggravate the difficulty of the whoosh, but a large amount of oxygen transfusion will make the partial pressure of oxygen in the blood increase, counteracting the excitatory stimulation of carbon dioxide on the whoosh center, but instead of inhibiting the whoosh center, resulting in the deterioration of the condition. Therefore, when giving oxygen to patients with pulmonary heart disease, it is better to use oxygen mixed with a certain concentration of carbon dioxide gas (generally, carbon dioxide accounts for 5% of the mixed oxygen, customarily known as 95 oxygen). A certain concentration of carbon dioxide in addition to excitation of the whoosh center, but also has the regulation of acid-base balance, dilate blood vessels and other effects. Because of the conditions, in many occasions, the oxygen used for patients is pure oxygen, and the principle of low flow and intermittent oxygenation must be mastered. The kind of thought that more oxygen is better, greedy for more fast to give oxygen ideas and practices, is contrary to the scientific principles, therefore, if the whooping failure, the patient’s family members must not think that more oxygen is beneficial. The patient’s family should not think that giving more oxygen is beneficial. They should think in terms of simple “giving oxygen for lack of oxygen”, or even force the medical staff to buy goods with the requirement of “adding more and more pounds and two more pounds”. In addition, inhalation of high concentrations of oxygen is harmful to the human body, greater than half the atmospheric pressure of oxygen on all cells have a detrimental effect, because high concentrations of oxygen can form a large number of oxygen free radicals in the tissue, oxygen free radicals can damage the tissue cell membranes, causing cells, organs, metabolism and dysfunction. Therefore, inhalation of more than half atmospheric pressure of oxygen for a long time may occur “oxygen toxicity”, oxygen toxicity is mainly damage to the lungs and brain, which can lead to pulmonary edema, pulmonary bruising and hemorrhage, lung lesions can seriously hinder the function of the whistle, so that the body of hypoxia aggravated. If inhaling 2~3 atmospheric pressure or even higher pressure oxygen, it may cause brain poisoning in ten minutes or several minutes, so that the brain cells undergo degeneration and necrosis, and the patient appears to have convulsions, coma and other neurological symptoms. Improper oxygen therapy for infants can also cause retinal damage, which can lead to blindness in severe cases. In addition to familiarizing themselves with the principles of oxygen administration for respiratory failure, medical personnel must also observe the condition at all times, and scientifically and reasonably grasp the time and flow of oxygen infusion. If there are conditions, it is better to transfuse the gas mixed with carbon dioxide. In the case of too much oxygen, we should use the assistive device for resuscitation. As patients and their families, they should fully understand the dual role of oxygen on the human body, use its favorable side and avoid its unfavorable side. In daily life, not only oxygen has duality, but also food, medicine, sports activities, mental labor, etc., only when moderate is good for health.