Repeated infections are the main symptom of hypogammaglobulinemia patients, and different parts of the infection will be associated with different symptoms, and some patients have the possibility of bleeding. 1. Infection: the most prominent clinical manifestation of hypogammaglobulinemia is repeated serious infections, especially respiratory tract infections are the most common, often with fever, cough, dyspnea and other symptoms. It can even be life-threatening. When the gastrointestinal tract is infected, nausea, vomiting, abdominal pain, diarrhea and so on can occur. When the urinary tract is infected, symptoms such as frequent urination, urinary urgency and painful urination can occur. 2. Bleeding: It is due to the low level of gammaglobulin, decreased immune function, and the coagulation function may be abnormal, resulting in multiple ecchymosis of the skin, bleeding from the mucous membrane of the mouth and nasal cavity, and other symptoms. When the level of gammaglobulin in the blood is low, you should go to the regular hospital in time.