Elevated creatinine after concomitant use of fenofibrate and epalrestat is primarily considered to be an adverse reaction to taking epalrestat. After taking Epalrestat, adverse reactions such as elevated creatinine, elevated bilirubin, and elevated AST can occur. And after taking fenofibrate, adverse reactions such as myalgia, rash, elevated transaminases, and dyspepsia can occur. Therefore, elevated creatinine after concomitant use of fenofibrate and epalrestat is mainly due to adverse reactions. Epalrestat non-competitively inhibits aldose reductase, improves peripheral nerve function, and can be used for diabetes-induced neuropathy. Urine may be maroon in color after administration, which is normal after administration. The interaction of this drug with other drugs is not known. It is contraindicated in people who are allergic to the drug. Fenofibrate belongs to the class of drugs called beta drugs, which lower blood cholesterol and are used in hypercholesterolemia. The drug interacts with statins such as atorvastatin and other fibrates such as clofibrate. Fenofibrate is contraindicated in the following cases: hypersensitivity to the drug; phototoxicity or photosensitization while taking fenofibrate or similar drugs; liver or kidney insufficiency; taking statins; taking medications; breastfeeding women; children. If you need to take the above drugs patients, please under the guidance of the doctor strictly follow the instructions of the doctor to take medication, do not self-medication.