The failure of insulin plus hypoglycemic drugs may be caused by patients’ failure to control diet, insulin resistance, improper operation of insulin injection, etc. It is recommended to consult a doctor in time and adjust the treatment program. 1. Diet control: If the blood glucose is still high after taking insulin plus hypoglycemic drugs, it may be caused by the lack of strict dietary control and the failure to reduce the source of sugar, so the patient should pay attention to strict dietary control. 2. Insulin resistance: some patients may have insulin resistance, so after taking insulin and hypoglycemic drugs, the blood glucose still cannot be controlled. The treatment program can be adjusted under the guidance of the doctor. 3. Improper operation of insulin injection: Some patients may inject insulin in an incorrect way, resulting in insulin does not play a role, which may also lead to blood glucose not coming down. You should learn the correct way of injecting insulin under the guidance of professional doctors. If there is a situation that the blood sugar still cannot be controlled after taking insulin and using hypoglycemic drugs, it is recommended to go to the hospital in time to find out the reason and make further adjustments according to the cause.