Chronic pancreatitis is not very well known and is not yet mainstream in China. The reason for this is that there are not many people suffering from it, and because it is not a fatal disease, most people do not take it seriously. However, for those who are in it, it is difficult to describe what it is like. Almost all patients with chronic pancreatitis have experienced the pain, which is the root cause of the pain of the slow pancreas. Even after the sudden onset of the pain, the dull pain that follows you around all the time during the long years of chronic pancreatitis torments your spirit until you collapse. In addition to pain, diarrhea, wasting, and the various struggles to control blood sugar also test the patient’s will. When faced with the pain of slow pancreas, the most convenient and quickest solution preferred by both patients and doctors is of course oral analgesics. The current global mainstream guidelines for the treatment of slow pancreas, medication is still the first line of treatment until the patient develops surgical complications. After years of pharmacological treatment, if the patient develops pancreatic stenosis or pancreatic duct obstruction, endoscopic treatment is preferred, and only when all measures fail is it the surgeon’s turn to take over. The principle of the above treatment plan is based on the “pancreatic self-destruction theory”. The current mainstream view is that chronic pancreatitis is a progressive inflammatory process that cannot be stopped by available means, and that neither medication nor surgery can stop its progression. Eventually, the pancreas will be replaced by connective tissue. The pain of slow pancreas, on the other hand, eventually disappears on its own as the pancreas destroys itself. Therefore, medication to control pain, supplementation and pancreatic enzyme replacement is safe and simple. Surgical intervention of slow pancreas when there are no surgical complications such as obstruction, the patient has to go through the pain of surgery, take the risk of surgery, and cannot stop the further deterioration of the disease, which is not worth the loss. However, is this really the case? During long-term observation, it was found that both after being tortured by slow pancreas for more than ten years and after the pancreas almost fibrosis, the pain remained and did not disappear due to the self-destruction of the pancreas. The pain, did it become a phantom, a figment of the brain’s imagination? It is really related to the brain. Some data show that in patients with slow pancreatic disease progression, there is a remodeling of the cerebral cortex, and if the remodeling is completed, the pain sensation is still difficult to eliminate even if the pancreas is fibrotic. With the current human technology, it is almost impossible to change the changes in the cerebral cortex. With long-term analgesic treatment, few people can resist the risk of addiction, and analgesic addiction is not much different from drug addiction. As a result, some scholars have begun to re-examine current treatment options. There are sporadic findings showing that surgery is better than endoscopic treatment for pain control, a study published in 2007 in one of the top journals in clinical medicine, with similar results for long-term follow-up. This was also followed by systematic evaluations that are now considered to have a high level of evidence confirming the idea – that open surgery is more effective than endoscopy. Clinical studies in the United States, Australia, and our own have found that early opening (within 3 years of encouraging onset) provides better control of pain than medication and improves the subsequent progression of deteriorating pancreatic function. The Japanese study even found that surgery reduced the incidence of pancreatic cancer in patients with slow pancreas compared to conventional treatment, pancreatic cancer oh. However, these few conclusions, the level of evidence is not high. To get a higher level of evidence, a clinical randomized controlled study comparing early surgery and conventional treatment options was initiated in Europe in 2013, which is the legendary way to get the best medical evidence. Unfortunately, however, no results have been reported until now. In summary, the combination of long-term slow pancreas can lead to brain problems and addiction to medication, and it is best to control inflammation and manage pain before either of these problems occur. Although there is no high-quality evidence that early surgery is necessarily better, it is a direction worth exploring. Perhaps early surgery, can improve the prognosis and improve the quality of life for patients with slow pancreas, although it takes a certain risk than taking medications, but how can you pursue a better life without taking risks? Our retrospective study has found that early surgery is indeed better. Of course, we need better evidence to support one of the findings.