The treatment of chronic pancreatitis is focused on pain control, diabetes and steatorrhea. Pain is probably the most difficult challenge in treatment, and medical, surgical and endoscopic treatments can control pain. 1. Internal treatment includes alcohol cessation, active treatment of biliary tract disease, suppression of gastric acid secretion, and supplementation with vitamins and short- and medium-chain fatty acids if necessary. Pancreatic enzyme replacement therapy can be used to suppress pancreatic exocrine secretion, and pancreatic enzyme therapy can be tried as the beginning of treatment for chronic pancreatitis, especially for patients with small pancreatic duct disease or idiopathic pancreatitis, especially for women. 2. Surgical treatment Surgery can be considered for those with the following indications: (1) Severe abdominal pain that has failed to respond to medical treatment. (2) Pancreatic cysts, pancreatic abscesses, pancreatic fistulas that have failed to respond to medical and minimally invasive surgical treatment. (3) Combined obstructive xanthogranuloma, duodenal and colonic obstruction. (4) Possible combination of pancreatic cancer. (5) Portal hypertension of pancreatic origin. The prerequisite for surgical decompression is main pancreatic duct dilation. Lateral pancreas-jejunostomy is the most widely used pancreatic duct decompression procedure with very satisfactory results. Evidence-based medical studies have shown that pancreaticoduodenectomy with preservation of the duodenum or pylorus can relieve 90%; of patients’ pain and improve their quality of life. However, in those without pancreatic duct dilatation, removal of most of the pancreatic head tissue will lead to considerable complications and a long-term risk of developing diabetes and pancreatic exocrine insufficiency, and the results of the procedure are not satisfactory. However, surgery is still regarded as an effective treatment for those who failed to undergo medical and endoscopic treatment. 3, endoscopic treatment With the continuous development of endoscopic treatment technology, endoscopic treatment of pancreatic diseases has also been widely carried out. Compared with surgical treatment, endoscopic treatment is less invasive and has a lower mortality rate, and it has been widely accepted as the preferred method to relieve abdominal pain caused by pancreatic duct obstruction. For pancreatic duct stenosis, EPS, balloon dilatation and pancreatic duct stenting can be used. Endoscopic mesh basket lithotomy, post-lithotripsy balloon lithotripsy, extracorporeal shock wave lithotripsy and internal stent placement for pancreatic duct drainage are feasible for pancreatic duct stones.