The diagnosis of chronic pancreatitis simply relies on clinical symptoms with imaging and pathological support. The clinical symptoms of the patient are as follows: 1, recurrent epigastric pain, and the pain is regular and can be relieved by lying on the elbow and knee, radiating to the lower back, mainly to the left upper abdomen; 2, abnormal blood amylase, and the appearance of pancreatic exocrine insufficiency, i.e., endocrine insufficiency, manifested as dyspepsia and steatorrhea; 3, abnormal blood sugar; 4, genetic testing of the patient’s pancreas reveals clear pathogenic mutations; 5 , the patient has long-term and heavy alcohol abuse. On the basis of these clinical symptoms, if pancreatic imaging is performed, the patient’s pancreas is found to be calcified with dilated and atrophied pancreatic ducts, and if conditions are available for histological testing of the pancreas, the patient’s pancreatic alveoli can be found to be significantly reduced and fibrotic, which can confirm the diagnosis of chronic pancreatitis.