Among the many complications of diabetes, diabetes combined with lower limb vasculopathy is one of the most common chronic complications, it refers to diabetes combined with atherosclerosis caused by lower limb artery disease, mostly occurs in older people over 60 years old, can cause lower limb pain, numbness, cold, ulcers, gangrene, diabetic foot, secondary infection, and even amputation and other serious consequences, is one of the main causes of disability of diabetic patients. According to statistics, more than one-fifth of diabetic patients with 5 years of disease combined with lower limb vasculopathy; more than 10 years of diabetes, two-thirds of the combined lower limb vasculopathy. The lower limb amputation rate of diabetic patients is 5-10 times higher than that of people without diabetes. In addition, diabetic lower extremity vasculopathy is often combined with myocardial infarction, cerebral infarction and other serious lesions, which greatly increases the mortality rate of patients. So, what are the manifestations of diabetes combined with lower extremity vasculopathy? When your lower extremities are cold, hot, numb, pins and needles pain, electric shock-like sensation and other abnormal sensations; or symmetrical “glove”-like sensory loss, insensitivity to pain, cold and heat; or lower extremity soreness, weakness, it is possible that diabetes combined with lower extremity vasculopathy. If you feel pain and soreness in your legs after walking a short distance (usually a few hundred meters or less) and have to stop and rest for a while before walking again, which is medically called intermittent claudication, it indicates lower limb ischemia caused by larger vascular lesions. When the lesion continues to develop, the ischemia of the lower extremity is aggravated, and pain occurs even when not walking, which is called resting pain, mostly in the toe and toe area, and the pain is aggravated when lying down at rest and at night, affecting sleep, which mostly indicates atherosclerosis occlusion of the lower extremity. In addition, the disease can also cause local malnutrition of the lower limbs, which can be seen as dry skin, poor elasticity, sweat hair loss, pale or purple skin, slow growth of toenails, deformation, hypertrophy, brittle crack, loss of luster, and muscle atrophy of the lower legs and feet. When the ischemia of the lower limbs is severe, ulcers and gangrene can occur at the extremities, complicating the diabetic foot, which does not heal for a long time. At present, the conventional treatment for this disease mainly includes hypoglycemia, hypotension, lipid lowering, vasodilatation, anticoagulation and antiplatelet aggregation. For severe stenosis of lower extremity vessels, lower extremity vascular intervention therapy can be used. In recent years, stem cell transplantation technology has also been gradually applied, and some patients have received this treatment, some of which have obvious effects, but the long-term effects remain to be observed. Internationally, there are also lower extremity arterial pressurization and perfusion methods to treat diabetic lower extremity vasculopathy. If the lower extremity vascular occlusion is severe and the ulcer or gangrene does not heal using the above methods, or if it continues to worsen, amputation treatment is required. Because the disease is difficult to treat, so diabetic friends should pay attention to early prevention, usually pay attention to the following aspects: 1, maintain a healthy, regular lifestyle is the basis for the prevention of diabetic lower limb vasculopathy. Diabetic patients should arrange a reasonable diet and exercise. Do not eat high-calorie, high-fat, high-cholesterol food, according to their own situation, choose appropriate walking, playing tai chi walking, jogging and other exercises, and maintain an optimistic mood. 2, strict control of blood sugar, blood pressure is an effective means to slow down the occurrence of lower limb vascular disease, diabetic patients should regularly monitor blood pressure, blood sugar, regular medication, blood pressure, blood sugar control in the normal range. 3, adhere to quit smoking, which can make patients reduce the risk of vascular disease. 4.Improve the circulation of the lower limbs. Strengthen the foot and calf activities, often massage the lower limbs to promote blood circulation in the lower limbs. 5, pay attention to the protection of the foot. Do not walk barefoot, wear loose, soft and comfortable, breathable shoes and socks; pay attention to warmth in autumn and winter to prevent frostbite; soak your feet in warm water for 10-15 minutes every day, it is best to try the water temperature by your family first, and then put your feet in the water, the temperature should be 37-39 ℃, so as not to burn your feet, ulcers, infections and other situations. Do not over-trim toenails, so as not to cut the toes; keep the skin lubricated to prevent cracking; check the foot every night before going to bed for trauma, infection, shoes have no stones and other foreign objects, so as not to hurt the foot, difficult to heal. 6.Actively treat foot lesions such as beriberi, chaps, tinea pedis, nail gouges, etc. to avoid the formation of diabetic foot. 7, pay attention to the observation of skin elasticity, color, temperature and local sensory abnormalities, early detection of diabetic lower limb vasculopathy signs. When you find that the lower limbs have cold, heat, numbness, pins and needles pain, electric shock-like sensation and other sensory abnormalities; or symmetrical “glove”-like sensory loss, insensitive to pain and cold, heat sensation; or leg soreness, weakness; or even intermittent claudication, resting pain, you should pay special attention. If you have a painful leg, you should go to a professional medical institution immediately and never take it lightly. 8, regular check of blood sugar, blood pressure, blood lipids, blood flow, lower limb vascular ultrasound, electromyography, etc., found abnormalities in a timely manner to professional medical institutions.