Palmoplantar pustulosis is a type of psoriasis, the etiology of which is not yet completely clear, and may be related to environmental factors, genetic factors, immune factors and so on. 1. Environmental factors: Changes in environmental factors, dry and cold climate may induce or aggravate psoriasis, in addition to infections, mental stress, trauma, obesity, alcoholism, smoking, stressful events, etc. may induce or aggravate psoriasis. 2. Genetic factors: some studies show that psoriasis has certain genetic tendency. 3. Immunity factors: the pathophysiological characteristics of psoriasis are related to the abnormal activation of T-lymphocytes, T-lymphocyte infiltration in the dermis or epidermis, which can indicate that psoriasis has a certain relationship with immunity factors. Palmoplantar pustulosis occurs as a result of a combination of immunologic factors, environmental factors, genetic factors, and other causes. When the diagnosis of palmoplantar pustulosis is confirmed, it is important to go to the hospital in time and follow the doctor’s instructions for treatment as early as possible.