Whether the patient’s pre-surgical enema will be accompanied by significant pain is based on the patient’s tolerance of pain, and whether the patient is combined with anal fissure, thrombosed hemorrhoids, perianal abscess and other perianal diseases to be objectively analyzed. First, if the patient’s pain tolerance is strong, the patient needs to perform surgery for gallbladder stones, the patient has not been combined with perianal abscess, perianal fissure and other perianal diseases, in this case to the patient’s enema, the patient is often not accompanied by obvious pain symptoms. Second, if the patient’s pain tolerance is poor, the patient because of acute suppurative appendicitis need to be operated on, at this time the patient combined with hemorrhoids, anal fistula or anal fissure perianal lesions, at this time for the enema may be stimulated to the mucous membranes of the perianal and rectal area, thus causing significant pain in the anus, and even accompanied by bleeding and other symptoms.