Nucleic acid testing after vaccination generally refers to nucleic acid testing for novel coronavirus after vaccination against novel coronavirus pneumonia, which has an effect at this time. At present, the vaccine widely used in China for the prevention of novel coronavirus pneumonia is an inactivated vaccine. Although the vaccine is inactivated, the principle of preventing the disease is to stimulate the body to produce antibodies through foreign antigens. If a nucleic acid test is performed at this time, a false-positive result may be detected if the antigen is detected. Therefore, it is theoretically necessary to wait at least 48 hours after receiving the new coronavirus pneumonia vaccine before conducting the nucleic acid test, and it is recommended to consult with the local CDC department for the exact interval to avoid other unnecessary effects on the test taker due to false positive results. It is also important to note that after receiving the new coronavirus pneumonia vaccine, try to avoid drinking alcohol, pay more attention to rest, and ensure balanced nutrition. If you experience strong discomfort after vaccination, you should seek medical attention immediately. Tip: The terms “new coronavirus pneumonia” and “new coronavirus pneumonia” mentioned in this article were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.