The author often hears such lamentations from patients’ families: mental illness is too difficult to treat, it is better than having cancer! Indeed, the etiology of mental disorders at home and abroad still needs to be studied in depth, and the causes of many mental illnesses are still unknown, which leads to difficulties in treatment and affects the efficacy of patients, and there are also many controversies about the treatment period of certain mental illnesses, resulting in clinical ineffectiveness and poor compliance with long-term treatment for certain diseases. However, are these factors alone responsible for the so-called difficulty in treatment and poor outcomes? No! The author believes that psychosomatic disorders are different from other physical diseases, which are influenced by many factors, including biological, social, family environment, interpersonal and psychological factors, among others, one or two of which can trigger an attack. The risk factors for outcome and relapse are summarized as follows: 1. Biological factors: including genetic susceptibility, neuroimmunoendocrine (such as the HPA axis, which is simply the central-endocrine-stress source), etc. These factors are influenced by somatic conditions and the internal environment, such as depression, which is influenced by both the external environment such as psychosocial (stress) and the internal environment such as endocrine and neurotransmitter changes, and sometimes more As some people say, we do not have psychological stimuli, our family is well-off and well-fed, how can we also get depression or schizophrenia? This may be the impact of biological susceptibility, which is not under human control. 2, social and personality factors: including the early childhood growth environment, family upbringing patterns, school environment and personality psychological development and other influences, during the onset and prognosis, if the above factors are not properly controlled conditioning, can also induce disease fluctuations or relapse. 3, stress and interpersonal relationships: in fact, they should also be classified as psychosocial factors, but in today’s society, these factors affect the psychological state of people, when they can not cope with the external environment, especially improper handling of interpersonal relationships, the pressure may be steeply aggravated, and the disease will be triggered in the long run. 4, social and occupational functions: At present, as long as you have a mental illness, almost no opportunity to enjoy the right to work, many patients with multiple sexually transmitted diseases, even if clinically cured, is also nothing to do, can only be idle at home, the lack of effective social interaction and work training for a long time, these abilities are significantly reduced, will also lead to recurrent disease, and eventually relapse. 5, love marriage: as Abraham Lincoln said: life is born to enjoy equality. Including love marriage, but this is not the case, they have almost no opportunity or right to enjoy this emotion, family members are also secretive, afraid to mention, afraid of children traumatized and relapse again, unknown, often this will also lead to the patient’s psychological distortion. Therefore, since the above factors are difficult to control all at once, the slightest impropriety may cause the condition to fluctuate, and the patient is a whole person who desires basic rights like all people, and when a certain wish cannot be met or the above risk factors increase, it may cause a relapse. Families and even patients themselves should have the right to understand the developmental characteristics of the disease and the risk of relapse, so that they can be prepared to respond positively and truly be “cured”! This is the responsibility of our psychiatric colleagues!