One year old babies with prolonged cough and fever are mostly seen in respiratory tract infections, such as bronchopneumonia, etc. Treatment requires symptomatic treatment with drugs such as ibuprofen and aminoglutethimide, as well as reasonable anti-infective treatment. For one year old baby fever, cough for a long time, mostly seen in respiratory tract infections, especially lower respiratory tract infections, such as acute bronchitis, bronchopneumonia, etc.. In addition to the above symptoms, may be accompanied by cough sputum unfavorable or wheezing and other symptoms, the examination can be heard irregular or fixed rales, improve the chest X-ray examination can assist in the diagnosis. For treatment, daily care should be strengthened, such as drinking plenty of water, paying attention to open windows and ventilation, etc., and using Ambrotyl oral solution to relieve cough symptoms. For babies with temperature over 38.5℃, antipyretic drugs (such as ibuprofen drops) can be reasonably used for symptomatic antipyretic, and inhalation budesonide suspension and other drugs should be used for nebulization treatment for severe cough. For suspected bacterial infections, antibacterial drugs, such as cefuroxime, should be used reasonably for anti-infective treatment, and follow the doctor’s instructions for a full course of treatment. The above drugs should be used under the guidance of a physician, avoid self-medication. Prolonged cough and fever in babies is recommended to actively consult a specialist to assess the condition and treatment.