Treatment of urticaria, take benadryl, cetirizine, loratadine, ibastine, fexofenadine, imipramine and other antihistamines are more effective, due to the different physical condition of the individual, the effect is also different, so there is no such thing as the most effective. Clinical treatment of urticaria preferred antihistamines. Antihistamines are divided into the first generation and the second generation. The first generation of antihistamines mainly include promethazine, phenylephrine, chlorpheniramine maleate, etc., can play a sedative central nervous system, relieve the symptoms of skin and mucous membrane allergies, when hives in the night attack and affect sleep, you can use the first generation of antihistamines, can relieve itching, improve the quality of sleep. Second-generation antihistamines, including cetirizine, loratadine, ebastine, etc., not only can be anti-allergic, but also inhibit the release of other inflammatory mediators, if the itching during the onset of severe, can be based on the use of second-generation antihistamines, plus a generation of antihistamines, in addition to the combination of calcium, vitamin C, reduce vascular permeability, and antihistamine drugs taken together to play a synergistic role. All of the above medications should be used under the guidance of a doctor, avoid self-medication, if the symptoms are not relieved, should be promptly admitted to the hospital for targeted treatment.