In patients with liver disease, the itching is usually generalized due to cholestasis causing jaundice, and is not limited to three areas, but may be more pronounced on the inner thighs, back, and so on. Liver disease refers to lesions of the liver, including hepatitis B, hepatitis A, hepatitis C, cirrhosis, fatty liver and liver cancer. Abnormalities in liver function can affect the metabolism of bile, raising bilirubin in the blood and causing jaundice, and can also cause deposition of bile, which can irritate the nerve endings of the skin and cause itching. The itching is usually generalized and not fixed in a certain area, but may be more sensitive in areas of the body where the skin is weak and rich in nerves, such as the inner thighs and back. Patients with itching symptoms, do not scratch the skin, so as not to break the skin caused by infection, it is recommended to follow the doctor’s instructions standardized treatment.