1. Pre-conception counseling is recommended. 2. When starting treatment for sle, they should be informed by the treating physician of the side effects caused by the drugs and their teratogenicity. 3. The need for good contraception during the use of MTX, LEF, CTX, and MMF should be remembered. 4. Patients with antiphospholipid syndrome in the absence of a characteristic past history (recurrent miscarriages and thrombosis of arteries), with elevated levels of lupus anticoagulants or anticardiolipin antibodies, should receive low doses of aspirin. Even low doses of heparin and aspirin in the absence of complications. 5. Patients with sLE with antiphospholipid syndrome should be monitored more frequently than patients with sLE alone.