High-grade gliomas in children include tumor types such as glioblastoma, mesenchymal astrocytoma, mesenchymal oligodendroglioma, and mesenchymal oligodendroglial astrocytoma. 1. Glioblastoma: its genetic test can see epidermal growth factor receptor overexpression, p53 gene mutation and so on. It is mostly found in all parts of the episodic cerebral hemisphere and is prone to recurrence. 2. Mesenchymal astrocytoma: it is mostly found in the brain and spinal cord, and most of the children first show headache and vomiting, and then develop coma and other serious neuropsychiatric symptoms. It is easy to recur and metastasize. 3. Mesenchymal oligodendroglioma: the tumor size is larger than oligodendroglioma, with hemorrhage and necrosis, higher malignancy, active proliferation and obvious intercellular degeneration. 4. Mesenchymal oligodendroglial astrocytoma: mostly found in the brain and spinal cord, originated from astrocytes, which may manifest as epilepsy, headache, nausea and other manifestations, and the tumor is more invasive. If you suspect the occurrence of the above tumors, it is recommended to go to the hospital for consultation in time.